This post may contain affiliate links, please see the privacy policy for details.
This cattle drive casserole is a baked dinner that comes out bubbling and deeply satisfying. A cheddar biscuit base sets up first, then a creamy taco-style beef layer goes on top with fire-roasted tomatoes, green chiles and plenty of cheese. You’ll find that it’s hearty enough for hungry people, simple enough for a weeknight and sturdy enough to cut into clean servings after a short rest.

Why You’ll Love It

Cattle drive casserole is a hearty layered bake with a cheddar biscuit base, creamy seasoned beef, fire-roasted tomatoes, green chiles and melted cheese.
One-dish dinner: Everything bakes in one pan which keeps cleanup easy.
Comforting and filling: It’s warm, cheesy and substantial.
Great texture: A tender biscuit base contrasts with a thick, creamy topping.
Leftovers are solid: It reheats well and still tastes great the next day.

More hearty dishes include cowboy stew, cowboy soup, cowboy meatloaf and potato casserole, cowboy sliders, and slow cooker cowboy beans.

Red Lobster Biscuit Casserole Ingredients
A complete list of ingredients and amounts can be found in the recipe card below.
Cheddar biscuit mix: Bakes into a savory base that holds the filling. Red Lobster Cheddar Bay biscuit mix works well, or you can use any biscuit brand.
Seasoning packet: Adds extra cheesy, savory flavor to the biscuit layer.
Olive oil: Helps brown the beef and soften the vegetables.
Ground beef: Brings rich, hearty flavor to the filling. Lean beef helps avoid a greasy casserole.
Yellow onion: Adds sweetness once softened.
Red bell pepper: Adds color and mild sweetness.
Taco seasoning packet: Brings bold, familiar Southwest flavor.
Smoked paprika: Adds a gentle smoky note that pairs with the tomatoes.
Ground cumin: Adds earthy warmth.
Sour cream: For tang and creaminess.
Mayonnaise: Makes the filling smoother and richer.
Fire-roasted diced tomatoes: Add smoky depth and body. Drain them well to avoid too much liquid.
Diced green chiles: Add mild heat and extra flavor.
Monterey Jack cheese: Melts smoothly through the filling.
Sharp cheddar cheese: Adds bite and a cheesy finish on top. Use freshly shredded cheese for better melting.

How to Make Cattle Drive Casserole
For more detailed instructions with weights and measurements, jump to the printable recipe card.
Start the base: Mix biscuit mix with water and the seasoning packet just until combined, spread evenly in a prepared casserole dish greased with cooking spray, and then par-bake until barely set.
Cook the beef: Brown the ground beef in a large skillet. Drain excess grease.
Soften the vegetables: Cook onion and bell pepper in the skillet until tender.
Season it: Stir in taco seasoning, smoked paprika and cumin until fragrant.
Add the veg mix-ins: Fold in drained tomatoes and drained green chiles.
Make it creamy: Stir in sour cream and mayonnaise until the mixture looks smooth.
Add cheese: Fold in shredded Monterey Jack and part of the shredded cheddar cheese.
Assemble: Spread the ground beef mixture evenly over the biscuit base and sprinkle the remaining cheddar on top.
Bake and rest: Bake in a preheated oven until the biscuit layer is cooked through and the casserole is bubbly.

Substitutions and Variations
Gluten-free version: Use a gluten-free cheddar-style biscuit mix and gluten-free taco seasoning, then check labels on the shredded cheese.
Ground meat swap: Ground turkey or ground chicken works well with the same seasonings.
Pepper swap: Use poblano instead of bell pepper for a mild heat.
Extra add-ins: Stir in corn or black beans for more texture, or try refried beans or green onions.
More spice: Add chopped jalapenos, cayenne, red pepper flakes or hot sauce if you want extra spice in this hearty casserole.
Cheese swaps: Try shredded pepper jack cheese, colby jack cheese or a combination.

Serving Suggestions
Appetizers: Begin with cowboy caviar dip and crackers.
Side dishes: Although cattle drive casserole is a standalone dish, you could pair it with a contrasting cool salad, such as this smoked potato salad or an iceberg wedge salad.
Desserts: Finish with Texas trash pie or Texas sheet cake cookies.

How to Store
Refrigerate: Store leftovers covered in the refrigerator and use within 3 days.
Freeze: Freeze baked or unbaked for up to 2 months.
Thaw: Defrost it in the refrigerator overnight.
Reheat: Warm single servings in the microwave, or reheat the whole dish covered in a 350°F oven until warmed through.

Top Tips
Mix lightly: Keep the biscuit layer tender by stirring just until combined and not over-mixing.
Drain well: Tomatoes and chiles should be well drained so the filling stays thick.
Better melt: Freshly shredded cheese melts more smoothly.
Cool a bit: Resting helps the layers set so servings stay neat.

Beef and Biscuit FAQs
Yes. Assemble it, cover it and refrigerate it for up to 1 day, then bake when ready.
Also known as John Wayne casserole, the name refers to the casserole being a satisfying and hearty meal that provides enough energy to sustain someone through a long, hard day at work, such as a cowboy on a historical cattle drive. With a nod to ranch-style cooking and filling, feed-a-crowd style dishes, the Southwestern flavors and baked, layered format is something you can scoop and serve to a hungry group fast.

Cattle Drive Casserole Recipe

Cattle Drive Casserole
Equipment
- Baking Dish 9 x 13-Inch
- Skillet Large
Ingredients
- 1 Package cheddar biscuit mix, 11.36-Ounce, plus included seasoning packet, I used Red Lobster
- ¾ Cup water
- 1 tablespoon olive oil
- 1 ½ Pounds ground beef, 85/15
- 1 yellow onion, small, finely chopped, about ½ Cup
- 1 red bell pepper, finely chopped, about ½ Cup
- 1 Package taco seasoning
- ½ Teaspoon kosher salt
- ½ Teaspoon smoked paprika
- ½ Teaspoon ground cumin
- ½ Cup sour cream
- ½ Cup mayonnaise
- 1 Can fire-roasted diced tomatoes, 15-Ounce, drained
- 1 Can diced green chiles, 4-Ounce, drained
- 1 Cup Monterey Jack cheese, shredded
- 1 Cup sharp cheddar cheese, shredded
- cooking spray, or melted butter, for greasing the dish
Instructions
- Preheat the oven to 375°F and grease a 9 x 13-inch baking dish.
Make the Biscuit Layer
- In a separate bowl, combine the biscuit mix with the water and seasoning packet from the box.
- Stir just until combined.
- Spread evenly over the bottom of the baking dish.
- Bake for 8 minutes just until the bottom is set but not baked through.
Prepare the Ground Beef Layer
- Heat olive oil in a large skillet over medium heat and add the ground beef. Cook until browned and fully cooked, then drain excess grease.
- Add the chopped onion and red bell pepper to the skillet and cook until softened.
- Stir in the taco seasoning, salt, smoked paprika, and cumin and cook for 1 minute until fragrant.
- Stir in the drained tomatoes and green chiles and remove from heat.
- Add the sour cream and mayonnaise and mix until smooth. Fold in the Monterey Jack cheese and half of the cheddar cheese.
Assemble and Bake the Casserole
- Spread the sour cream mixture evenly over the biscuit base.
- Sprinkle the remaining cheddar cheese over the top.
- Bake uncovered until the biscuits are cooked through and the filling is bubbling hot.
- Cool briefly so the layers set, then slice and serve.
Notes
Drain well: Tomatoes and chiles should be well drained so the filling stays thick.
Better melt: Freshly shredded cheese melts more smoothly.
Cool a bit: Resting helps the layers set so servings stay neat.
Nutrition









Cattle drive casserole is a dependable dinner when you want something hearty that doesn’t require a lot of separate sides or extra work. The biscuit base gives it that cozy, homemade vibe, while the creamy taco beef topping keeps every bite rich and satisfying. Let it rest for a few minutes, then cut into squares and serve while it’s hot and bubbly. If there are leftovers, they reheat well and make an easy lunch the next day.
Other Recipes to Try












